Abstract:TC4 Titanium alloy is a typical difficult-to-machine material, and its cutting surface quality is difficult to con-trol. In order to optimize the cutting process parameters for peripheral milling surface morphology, experimental research on TC4 titanium alloy peripheral milling is carried out. Firstly, the characteristics and formation mechanism of micro de-fects on the machined surface are explored; secondly, the surface morphology of milling is quantitatively characterized us-ing roughness parameters Ra and Sa, and the effects of cutting speed, feed rate, and cutting depth on surface roughness pa-rameters are analyzed; finally, the milling process parameters are optimized based on the genetic algorithm. Research has found that the micro defects on the machining surface mainly include inherent defects such as feed marks and random de-fects such as attached particles. The surface roughness of milling first decreases and then increases with the increase of spindle speed, increases and then decreases with the increase of radial cutting depth, and increases and then decreases with the feed rate. Under the conditions of spindle speed n = 1 093 r/min, radial cutting depth ae = 0.2 mm, and feed rate per revolution f = 0.06 mm/r, smaller surface roughness can be obtained.